Kalite
Myoglobin, creatine kinase (CK-MB), and Troponin I are the three most common cardiac markers.
Myoglobin is a hemeprotein typically found in skeletal and cardiac muscle and is responsible for transporting oxygen within muscle cells. Due to its small size, Myoglobin levels rise quickly (within two hours) of muscle injury, peak in 10 hours, and return to baseline within 24-36 hours.
However, since it is not specific to cardiac muscles, results need confirmation with other cardiac markers.
Creatine kinase (CK) is an enzyme that converts creatine to phosphocreatine using Adenosine triphosphate (ATP) and vice versa. CK is expressed in various tissues (especially tis- sues consuming ATP rapidly) in the human body.
CK-MB (Cardiac specific) levels elevate more slowly (3-12 hours), peak in 9 to 30 hours, and remain elevated before it returns to baseline levels within 48 to 72 hours.
The difference in the periods in which each of Myoglobin, CK-MB, and Troponin I rise provides an excellent and wide window for identifying heart conditions.
Observing the levels of these proteins is vital in the treat- ment process as well.
INTENDED USE
Turklab’s Myoglobin / CK-MB / Troponin I Test is a immuno- chromatographic test for the qualitative detection of human cardiac marker Myoglobin, CK-MB and Troponin I in human whole blood / serum / plasma to aid diagnosis of myocardial infarction (MI).
• Simultaneos sensetive detection of 3 important cardiac markers.
• Verified (tested, established) non-reactivity with skletal Troponin I, Troponin T, CK-MM, CK-BB, and cardiac myosin.
| For Myoglobin: | For CK-MB: | For Troponin I ; |
| Sensitivity: 99,9% | Sensitivity: 99,9% | Sensitivity: 99,4% |
| Specificity: 98,0% | Specificity: 99,7% | Specificity: 98,2% |